Title:- Role of Tab Parijataka in
the management of sheetpurvak jwara ( Malaria)
Dr. Aparna
V. Deshpande had submitted her dissertation to Pune University
for the P. G. degree M.D. (Kaya Chikitsa) in the year 1999. Her guide was Prof.
Dr. P. H. Kulkarni & Research center was Tilak Ayurved Mahavidyalaya, Pune,
(M.S.) India.
Dr.
Aparna V. Deshpande in her research work tried to evaluate role of parijataka
guti in the management of sheetpurvak jwara.
Patients
were treated with parijataka guti in the
dose of 1.5 gm with lukewarm water three times a day at 8 am, 2 pm & 8 pm.
Duration of the treatment was 7 days.
Temperature
chart of the patients was maintained every two hourly and as per need.
For
clinical study 50 patients were selected.
Criteria for assessment of cure was as follows-
1) Decreased frequency of
rigors/chills,
2) Decreased temperature
3) Sweating
4) Agnivaradhana.
Animal
experiments were also carried out to study anti-inflammatory activity of
parijataka guti.
Methods used are as follows-
A) Rat paw edema – An irritant is injected into subcutaneous tissue on
the planter aspects to rat hind paw to produce inflammation. The resultant
swelling is measured by plethysmometer at different intervals. Formaldehyde
carageenan, yeast, egg white, kaolin is some of the common irritant used. (
winter et al 1962 )
B) Cotton pellet granuloma method – Sterile cotton pellets of known weight
are implanted into the subcutaneous tissue. The animals are dosed orally, daily
for seven days. The pellets are then removed with the surrounding granulation
tissue and dried overnight till constant weight (Satoskar & Bhandarkar,
1993).
Standard operating procedure for
plethysmometer 7140 was adopted calibration
of the instrument was carried out with the help of volume probes.
The
percentage inhibition was calculated by using the formula.
%
inhibition = [1 – Vd – Vp/Vc-Vp ] x 100
Vd – Vp = Difference in paw volume
after carageenan injection & initial paw volume for drug treated animal.
Vc – Vp = Difference in paw volume
after carageenan injection & initial paw volume for control animals.
The study was concluded as follows-
When Tab Parijataka was given in
the dose of 1.5 gm TDS ,with lukewarm water for 7 days ,was found useful in the
patients of Malaria.
Chi square test & T. Test are
proved to be significant 0.5% probability i.e. 95% people can be cured. But
actually case studies show 80% patients cured completely while 12% patients got
partial relief & 8% of patients did not responded to the therapy.
Parijataka guti is found to be more
effective mainly on pranavaha srotas and annavaha srotas.
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