Title:- Efficacy of ‘Trushanadi Takram’ in Udara( Ascites) with special reference to S.G.P.T, S.G.O.T and
serum proteins.
Dr. Bhalchandra
R. Mahamuni had submitted his dissertation to Pune University
for the P. G. degree M.D. (KayaChikitsa) in the year 2007. His guide was Dr. Sadanand
Deshpande & Research center was Tilak Ayurved Mahavidyalaya, Pune, (M.S.) India.
Dr.
Bhalchandra R. Mahamuni in his research work tried to assess efficacy of
‘Trushanadi Takram’ as agnivardhana Chikitsa (Apetiser) in Jatodak avastha of Udara
(Ascitis) with special reference to S.G.P.T, S.G.O.T & serum proteins.
30
patients were selected for clinical study. Age group between 20 to 60 yrs was
preferred.
Drug was prepared as follows-
i)
Sunthi
( Zingiber officinale) – root steam 1
part
ii)
Pippali
( Piper longum) – fruit 1 part
iii)
Maricha
(Piper nigrum) – fruit 1 part
iv)
Yavakshara
churna 1 part
v)
Saindhav
churna 1 part
vi)
Takra
(Buttermilk) 40 ml.
Trushanadi
churna – 5 gm & Takra 80 ml. Dosage schedule was
designed as 40 ml medicated buttermilk twice a day for 21 days. Route of administration was oral. Criteria for assessment were as
follows-
1)
Adhmana – Adhmana was measured by measuring
tape at three levels. a) Abdominal girth 8 cm above umbilicus, b) on umbilicus.
C) 8cm below umbilicus.
2)
Bipadal oedema – was also measured by measuring
tape at three levels a) 6 cm from the tip of the toe, b) at the level above
ankle, c) 2 cm below knee joint.
3)
Abhyavarana Shakti – i) grade 0 = intake upto 1liters,
ii) grade 1 = intake 1 to 2 liters, iii) grade 2 = intake upto 2 to3 liters iv)
grade 3 = intake above 3 liters.
4)
Jaran shakti – liquid diet was given &
digestion time required for the consumed diet at what time patient was hungry
& had udara laghava was assessed i) Grade 0 = none, ii) Grade 1 = upto 12
hrs, iii) Grade 2 upto 6 hrs & iv) Grade 3 = upto 3 hrs.
5)
Samata – was observed on jivha. Photograph
of jivha was taken for easy assessment & gradation was given i) Grade 0 =
severely white coated tongue, ii) Grade 1 = moderately coated, iii) Grade 2 =
mildly coated & iv) Grade 3 = Nirama.
Objective criteria- S.G.O.T., S.G.P.T. & Sr. Protiens levels.
Study was concluded as follows-
When 40 ml Medicated Buttermilk ,processed with Trushanadi churna was given to Patients
of Ascites ,remarkable improvement was seen in various symptoms with reduction
of SGOT & SGPT levels .
Patients showed reduction in duration of jarana by three
hours. Reduction in samata was observed from grade 3 to grade 2 means mildly
coated. There is average weight reduction 2 kg after takrapana. In other
subjective criteria like abdominal distension, bipedal oedema, udara shool,
malasanga, nidravaiparyaya patient showed significant reduction. S.G.O.T.,
S.G.P.T. levels were reduced with increase of Sr. protein level. Trushanadi
takra was more useful in kapha vataja udara. No side effects of drug were
observed.
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